Detailed view for Rv3602c

Basic information

TDR Targets ID: 6639
Mycobacterium tuberculosis, Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme)
Source Database / ID:  Tuberculist 

pI: 5.953 | Length (AA): 309 | MW (Da): 32678 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF02569   Pantoate-beta-alanine ligase

Gene Ontology

Mouse over links to read term descriptions.
GO:0004592   pantoate-beta-alanine ligase activity  
GO:0015940   pantothenate biosynthetic process  

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
3 290 1mop (A) 3 290 99.99 0 1 2.12524 -1.02
11 185 3guz (A) 1 176 48.00 0 1 1.19924 -1.44

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

PDB tag
  • 1MOP:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 1N2B:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
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  • 1N2E:
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  • 1N2G:
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  • 1N2H:
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  • 1N2I:
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  • 1N2J:
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  • 1N2O:
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PDB tag
  • 2A7X:
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PDB tag
  • 2A84:
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  • 2A86:
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PDB tag
  • 2A88:
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PDB tag
  • 3COV:
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  • 3COW:
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  • 3COY:
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PDB tag
  • 3COZ:
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PDB tag
  • 3IMC:
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PDB tag
  • 3IME:
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PDB tag
  • 3IMG:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 3IOB:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 3IOC:
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PDB tag
  • 3IOD:
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PDB tag
  • 3IOE:
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PDB tag
  • 3ISJ:
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PDB tag
  • 3IUB:
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PDB tag
  • 3IUE:
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PDB tag
  • 3IVC:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 3IVG:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 3IVX:
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PDB tag
  • 3LE8:
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PDB tag
  • 4DDH:
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PDB tag
  • 4DDK:
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  • 4DDM:
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PDB tag
  • 4DE5:
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PDB tag
  • 4EF6:
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PDB tag
  • 4EFK:
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PDB tag
  • 4FZJ:
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PDB tag
  • 4G5F:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 4G5Y:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 4MQ6:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 4MUE:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 4MUF:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 4MUG:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 4MUH:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 4MUI:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 4MUJ:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 4MUK:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 4MUL:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 4MUN:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date

Expression

Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile Dormant phase. hasan
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile Dormant phase. murphy
Show/Hide expression data references
  • hasan Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis.
  • murphy Identification of gene targets against dormant phase Mycobacterium tuberculosis infections.

Orthologs

Ortholog group members (OG5_129569)

Species Accession Gene Product
Arabidopsis thaliana AT5G48840   pantoate--beta-alanine ligase
Dictyostelium discoideum DDB_G0288935   pantoate-beta-alanine ligase
Escherichia coli b0133   pantothenate synthetase
Mycobacterium leprae ML0230   Probable pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme)
Mycobacterium tuberculosis Rv3602c   Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme)
Mycobacterium ulcerans MUL_4184   pantoate--beta-alanine ligase
Neospora caninum NCLIV_039640   pantoate--beta-alanine ligase, putative
Oryza sativa 4334806   Os03g0851800
Saccharomyces cerevisiae YIL145C   pantoate--beta-alanine ligase PAN6
Toxoplasma gondii TGME49_265870   pantoate-beta-alanine ligase

Essentiality

Rv3602c has direct evidence of essentiality
Gene/Ortholog Organism Phenotype Source Study
mtu3664 this record Mycobacterium tuberculosis essential nmpdr
b0133 Escherichia coli non-essential goodall
TGME49_265870 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84

Phenotypes and Validation (curated)

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Drugs/Inhibitors
growth (GO:0040007) auxotroph (PATO:0000422) inferred from loss-of-function mutant phenotype (ECO:0000016) Mycobacterium smegmatis No drug identifiers listed for this gene.
Annotator: crowther@u.washington.edu. Comment: 2007-12-31. References: 12368434
growth (GO:0040007) auxotroph (PATO:0000422) inferred from loss-of-function mutant phenotype (ECO:0000016) Mycobacterium bovis No drug identifiers listed for this gene.
Annotator: crowther@u.washington.edu. Comment: 2007-12-31. References: 12368434
growth (GO:0040007) auxotroph (PATO:0000422) inferred from loss-of-function mutant phenotype (ECO:0000016) Mycobacterium tuberculosis No drug identifiers listed for this gene.
Annotator: crowther@u.washington.edu. Comment: 2007-12-31. References: 12368434
catalytic activity (GO:0003824) decreased (PATO:0000468) inferred from specific protein inhibition (ECO:0000020) Mycobacterium tuberculosis 558416  
Annotator: crowther@u.washington.edu. Comment: 2007-12-31. References: 17175524

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.2

Known modulators for this target

109 chemical compounds are associated with this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Mycobacterium leprae Probable pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0837 0.2698 0.6626
0.1801 1 1
0.1766 1 1
0.8492 1 1
0.0581 1 1
0.3722 0.6396 1
0.1782 0.5109 1
0.3828 0.6404 1
0.0725 0.8888 1
0.4577 0.4221 1
0.3247 0.2834 0.2834
0.0602 0.4498 0.4498
0.0607 1 0.5
0.0393 1 1
0.5156 1 1
0.0671 0.8148 0.5
0.058 0.2662 0.3356
0.1206 0.8554 0.5
0.3247 0.2834 0.2834
0.0581 1 1
0.1283 0.97 1
0.3159 0.7121 1
0.0582 0.7251 1
0.2657 0.2633 1
0.3283 1 1
0.5684 1 1
0.3075 0.6035 1
0.8321 1 1
0.0399 0.8866 1
0.1782 0.5109 1
0.0625 0.6554 1
0.0749 0.9336 1
0.2564 0.5842 1
0.0494 0.5738 0.6212
0.1782 1 1
0.3745 1 1
0.2573 0.4901 1
0.0643 0.8075 1
0.0597 1 1
0.0494 0.5738 0.6212
0.0589 0.8552 1
0.0638 0.8019 1
0.0649 0.2533 0.9335
0.1782 0.5109 1
0.0778999 1 1
0.2412 0.6025 1
0.058 0.4341 0.434
0.0791 1 1
0.0895 1 0.5
0.2432 0.5 0.5
0.1166 1 1
0.8591 1 1
0.1283 0.97 1
0.0627 0.7835 0.7735
0.0666 0.7642 0.9683
0.0607 0.3491 1
0.0725 0.7385 1
0.0725 1 0.5
0.0627 0.8856 1
0.0592 0.3738 1
0.419 1 1
0.4373 1 1
0.3159 0.9725 1
0.3736 1 1
0.0627 0.3785 0.5
0.2436 1 1
0.063 0.7812 1
0.2454 0.7317 1
0.2444 0.4813 1
0.1782 0.5109 1
0.0659 0.4246 0.4244
0.0601 0.8214 0.5
0.0369 0.2671 0.4682
0.058 0.4565 1
0.0725 1 0.5
0.06 0.7092 1
0.3159 0.4551 1
0.2444 0.4813 1
0.1807 1 1
0.3178 1 1
0.3197 1 1
0.323 0.2825 1
0.0582 0.3364 0.8251
0.0592 0.7166 0.5
0.0622 0.9667 0.5
0.2572 1 1
0.4552 0.7623 1
0.8291 1 1
0.3144 0.3551 0.9464
0.1172 0.3489 1
0.0597 0.7537 1
0.058 0.4341 0.434
0.4379 1 1
0.0443 0.2756 1
0.3806 1 1
0.1604 0.2585 0.3574
0.4358 1 1
0.0634 0.8547 1
0.0397 0.8869 1
0.323 0.2825 1
0.3144 0.3551 0.9464
0.323 0.2825 1
0.2341 1 1
0.0725 0.731 1
0.3357 0.4951 0.495
0.0608 0.5 0.5
0.1203 0.75 1
0.0601 0.8214 0.5
0.0599 1 1
0.3159 0.4551 1
0.3247 0.2834 0.2834
0.0725 0.5408 1
0.323 0.2825 1
0.3867 1 0.5
0.5131 1 1
0.2341 1 1
0.2487 0.5738 1
0.4577 0.4221 1
0.0725 0.5134 1
0.3159 0.7121 1
0.3159 0.9725 1
0.1175 1 1
0.1219 1 0.5
0.4373 1 1
0.0725 1 0.5
0.3159 0.7121 1
0.4813 1 1
0.3711 1 1
0.0604 1 1
0.3159 0.7121 1
0.0599 1 0.5
0.3773 1 1
0.1176 0.6568 1
0.3739 1 1
0.796 1 1
0.1191 0.5 0.5
0.3144 0.3551 0.9464
0.0597 0.7494 0.5
0.0679 0.4114 0.5
0.0369 0.4683 0.4682
0.2864 0.592 1
0.3903 1 1
0.2657 0.2633 1
0.0588 0.8289 0.8475
0.18 1 1
0.3006 0.8816 1
0.059 0.3091 0.3091
0.058 0.4565 1
0.2657 0.2633 1
0.3159 0.4551 1
0.3319 0.6456 0.6451
0.1903 0.4546 1
0.1186 0.7852 1
0.0625 0.6554 1
0.0772174 0.5 0.5
0.0584 0.9311 1
0.2341 1 1
0.1172 0.3489 1
0.248 1 0.5
0.2657 0.2633 1
0.491126 1 0.5
0.4577 0.4221 1
0.3925 0.6466 1
0.3159 0.4551 1
0.0749 0.9336 1
0.3159 0.7121 1
0.0725 0.5 0.5
0.3886 0.6463 1
0.0671 0.8148 0.5
0.06 0.6194 0.5
0.4379 1 1
0.0422 0.8869 1
0.2573 0.4901 1
0.0666 0.7642 0.9683
0.0725 0.7384 1
0.0602 0.6039 1
0.1815 0.2616 1
0.4373 1 1
0.3159 0.7121 1
0.0698 0.8288 1
0.1343 1 0.5
0.4379 1 1
0.1211 1 1
0.3114 1 1
0.06 0.362 1
0.4296 1 1
0.3075 0.6035 1
0.3746 1 1
0.1808 0.429 1
0.4385 0.8793 1
0.0545 1 1
0.1272 1 1
0.3159 0.9725 1
0.3773 1 1
0.8291 1 1
0.1186 0.7852 1
0.0606 0.7101 1
0.3159 0.7121 1
0.0684 0.567 0.5656
0.323 0.2825 1
0.06 1 1
0.1796 1 1
0.0725 0.6588 0.6894
0.8254 1 1
0.0608 1 1
0.0606 1 1
0.0581 0.9597 0.9597
0.0581 1 1
0.042 0.2775 0.4668
0.1133 0.5048 1
0.0771 0.5016 1
0.0725 1 1
0.0725 1 0.5
0.0374 0.8869 1
0.06 1 1
0.3159 0.9725 1
0.0698 0.7924 1
0.3342 1 1
0.064 0.6566 1
0.0584 1 1
0.2566 0.4269 1
0.3196 1 0.5
0.0627 0.7835 0.7735
0.0597 0.7537 1
0.0725 0.2848 1
0.2451 0.7469 1
0.0583 0.2796 0.5214
0.3159 0.7121 1
0.3012 1 1
0.1815 0.428 1
0.1394 1 1
0.0679 0.4045 0.5
0.331258 0.488129 1
0.2412 0.6025 1
0.552 1 0.5
0.0601 1 1
0.3263 0.5 0.5
0.2535 0.3184 0.3184
0.32076 1 0.5
0.0725 0.4761 1
0.5068 1 1
0.0757 0.315 0.3145
0.323 0.2825 1
0.3072 1 0.5
0.3159 0.7121 1
0.2389 0.4857 1
0.2551 0.6034 1
0.0601 0.8214 0.5
0.0584 1 1
0.5137 1 1
0.0681 0.414 1
0.2564 0.5087 1
0.1797 1 1
0.0591 1 1
0.4934 0.8185 1
0.0603 0.7507 1
0.3283 1 1
0.0494 0.5738 0.6212
0.323 0.2825 1
0.0617 0.884 1
0.0585 1 1
0.0725 1 0.5
0.0725 0.5408 1
0.8912 1 1
0.0725 0.731 1
0.2487 0.5738 1
0.0612 1 1
0.1181 1 1
0.5133 1 1
0.0677 0.41 0.5
0.059 1 1
0.4577 0.4221 1
0.0618 0.6657 1
0.1209 1 1
0.0594 1 1
0.5137 1 1
0.117 1 1
0.0725 0.7092 1
0.8867 1 1
0.0725 1 1
0.0422 0.8869 1
0.0605 0.8582 1
0.5541 0.5234 1
0.492 0.5708 1
0.0631 0.7241 1
0.27 0.4767 0.4767
0.4577 0.4221 1
0.0632 1 1
0.2347 0.5907 1
0.2347 0.5907 1
0.3319 0.6466 0.6462
0.0668 0.8539 1
0.3877 1 1
0.1782 0.5109 1
0.1133 0.5048 1
0.3159 0.4551 1
0.0675 0.6856 1
0.7989 1 1
0.1186 0.7852 1
0.3144 0.3551 0.9464
0.2531 1 1
0.2452 0.7247 1
0.3263 0.5 0.5
0.1189 0.4573 1
0.2542 1 1
0.0649 0.2533 0.9335
0.1496 0.3046 1
0.253 0.6129 1
0.1782 0.5109 1
0.1892 0.7418 1
0.1133 0.5048 1
0.1873 1 0.5
0.1319 0.797 0.5
0.0725 0.5 0.5
0.0627 0.7835 0.7735
0.0582 0.3364 0.8251
0.1827 0.5431 1
0.1782 0.5109 1
0.3144 0.3551 0.9464
0.2475 0.721 1
0.0602 1 0.5
0.3159 0.4551 1
0.0684 0.567 0.5656
0.0603 0.8778 1
0.0603 1 1
0.3159 0.9725 1
0.1801 1 1
0.3144 0.3551 0.9464
0.3178 1 1
0.2341 1 1
0.1761 0.5064 1
0.0725 1 0.5
0.1822 1 1
0.0602 0.3346 1
0.0616 1 0.5
0.0598 0.4717 1
0.3722 0.6396 1
0.0725 0.5 0.5
0.8174 1 1
0.0616 1 0.5
0.0394 0.2782 0.305
0.2417 1 0.5
0.3159 0.7121 1
0.0594 0.8856 1
0.3637 1 1
0.0784 0.4228 1
0.2615 0.6577 0.6569
0.3075 0.6035 1
0.3159 0.9725 1
0.349505 0.481362 0.481307
0.2532 1 0.5
0.5208 0.5 0.5
0.0725 0.2937 1
0.1278 0.9465 0.9464
0.0592 0.348 1
0.2751 0.8593 1
0.0725 0.5408 1
0.385 1 1
0.3144 0.3551 0.9464
0.0725 0.731 1
0.3159 0.7121 1
0.313 1 1
0.3664 1 1
0.1782 0.5109 1
0.2412 0.6025 1
0.2474 0.5985 1
0.3159 0.7121 1
0.0725 0.5 0.5
0.0583 0.611 1
0.3247 0.2834 0.2834
0.4577 0.4221 1
0.0725 1 0.5
0.2556 1 1
0.0725 1 1
0.0725 0.3926 0.5
0.0625 0.6219 0.5
0.1206 0.8554 0.5
0.4373 1 1
0.5537 1 0.5
0.3039 0.7367 1
0.1283 0.97 1
0.4813 1 1
0.2656 0.5082 1
0.3847 0.6465 1
0.1981 0.3757 1
0.388 1 0.5
0.1815 0.428 1
0.2598 0.6115 1
0.0582 0.3437 1
0.3159 0.9725 1
0.0601 0.3772 1
0.331258 0.488129 1
0.4577 0.4221 1
0.1199 0.8912 0.891
0.3159 0.7121 1
0.0628 1 0.5
0.0596 0.3595 0.4427
0.3144 0.3551 0.9464
0.3144 0.3551 0.9464
0.0399 0.8869 1
0.4596 0.7863 1
0.3144 0.3551 0.9464
0.1209 1 1
0.1198 0.4873 1
0.1125 0.4234 1
0.313 1 1
0.0667 0.2748 1
0.2564 0.5842 1
0.0612 0.4053 1
0.33 0.7431 0.7427
0.0587 0.3393 1
0.5102 1 1
0.0725 0.746 1
0.0627 1 1
0.1394 1 1
0.492 0.5708 1
0.1903 0.5555 1
0.243 0.4859 1
0.0812 0.5 0.5
0.0605 0.8582 1
0.4379 1 1
0.2564 0.5842 1
0.0397 0.8869 1
0.331258 0.488129 1
0.3138 0.7457 1
0.0584 0.7419 1
0.245 0.3366 0.3366
0.2496 0.418 1
0.0725 0.3372 0.5
0.2894 1 1
0.0399 0.8869 1
0.265 1 1
0.042 0.4683 0.4668
0.0681 0.414 1
0.0584 0.9311 1
0.0692 0.4115 1
0.0601 0.8214 0.5
0.0625 0.2564 1
0.0673 0.4024 0.5
0.2462 1 1
0.0725 1 0.5
0.0725 0.4483 1
0.1808 0.429 1
0.3731 1 1
0.2497 1 1
0.0725 0.8888 1
0.7416 1 1
0.0628 0.9567 0.5
0.059 0.3518 1
0.2564 0.5842 1
0.323 0.2825 1
0.1782 0.5109 1
0.0494 0.5738 0.6212
0.0625 1 1
0.0651 1 1
0.0604 0.3729 1
0.3159 0.7121 1
0.2609 0.6111 1
0.0602 0.6792 0.5
0.2454 0.7317 1
0.323 0.2825 1
0.2412 0.6025 1
0.0725 0.4529 1
0.5646 0.291 1
0.7416 1 1

Assayability

Assay information

  • Inhibition of Mycobacterium tuberculosis pantothenate synthetase at 100 uM ChEMBL
  • Inhibition of Mycobacterium tuberculosis pantothenate synthetase at 100 uM
  • Inhibition of Mycobacterium tuberculosis pantothenate synthetase ChEMBL
  • Inhibition of Mycobacterium tuberculosis pantothenate synthetase
  • ChEMBL
  • Competitive inhibition of Mycobacterium tuberculosis Pantothenate synthetase by ITC method
  • ChEMBL
  • Inhibition of Mycobacterium tuberculosis Pantothenate synthetase
  • ChEMBL
  • Binding affinity to Mycobacterium tuberculosis Pantothenate synthetase
  • ChEMBL
  • Binding affinity to Mycobacterium tuberculosis Pantothenate synthetase ATP-binding site by ITC method
  • ChEMBL
  • Binding affinity to Mycobacterium tuberculosis pantothenate synthetase assessed as alpha-helix structural changes by circular dichroism spectra analysis (Rvb = 47.93 %%)
  • ChEMBL
  • Binding affinity to Mycobacterium tuberculosis pantothenate synthetase assessed as beta-sheet structural changes by circular dichroism spectra analysis (Rvb = 8.19 %%)
  • ChEMBL
  • Binding affinity to Mycobacterium tuberculosis pantothenate synthetase assessed as alpha-helix structural changes by crystal structure analysis (Rvb = 41.3 %%)
  • ChEMBL
  • Binding affinity to Mycobacterium tuberculosis pantothenate synthetase assessed as beta-sheet structural changes by crystal structure analysis (Rvb = 21.3 %%)
  • ChEMBL
  • Inhibition of Mycobacterium tuberculosis pantothenate synthetase by high throughput screening method
  • ChEMBL
  • Binding affinity to Mycobacterium tuberculosis pantothenate synthetase by tryptophan fluorescence quenching assay
  • ChEMBL
  • Inhibition of Mycobacterium tuberculosis pantothenate synthetase at 50 uM by high throughput screening method relative to control
  • ChEMBL
  • Competitive inhibition of Mycobacterium tuberculosis pantothenate synthetase using ATP by Dixon plot analysis
  • ChEMBL
  • Competitive inhibition of Mycobacterium tuberculosis pantothenate synthetase using beta-alanine by Dixon plot analysis
  • ChEMBL
  • Inhibition of Mycobacterium tuberculosis pantothenate synthetase
  • ChEMBL
  • Binding affinity to Mycobacterium tuberculosis pantothenate synthetase
  • ChEMBL
  • Inhibition of Mycobacterium tuberculosis pantothenate synthetase cloned in Escherichia coli BL21 (DE3) using ATP, beta-alanine, pantoic acid as substrate assessed as NAD+ production measured every 12 secs for 120 secs by spectrophotometric analysis
  • ChEMBL
  • Inhibition of Mycobacterium tuberculosis pantothenate synthetase cloned in Escherichia coli BL21 (DE3) using ATP, beta-alanine, pantoic acid as substrate assessed as NAD+ production at 100 uM measured every 12 secs for 120 secs by spectrophotometric analysis relative to control
  • ChEMBL
  • Competitive inhibition of Mycobacterium tuberculosis recombinant PanC expressed in Escherichia coli BL21 (DE3) using pantoic acid and ATP as substrate by Michaelis-Menten equation analysis
  • ChEMBL
  • Binding affinity to Mycobacterium tuberculosis pantothenate synthetase expressed in Escherichia coli BL21 (DE3) assessed as increase in thermal stability (Rvb = 46.70 degC)
  • ChEMBL
  • Inhibition of Mycobacterium tuberculosis pantothenate synthetase expressed in Escherichia coli BL21 (DE3)
  • ChEMBL
  • Inhibition of Mycobacterium tuberculosis pantothenate synthetase expressed in Escherichia coli BL21 (DE3) by spectrophotometry
  • ChEMBL
  • Binding affinity to Mycobacterium tuberculosis pantothenate synthetase assessed as melting temperature by differential scanning fluorimetry
  • ChEMBL
  • Inhibition of Mycobacterium tuberculosis pantothenate synthetase
  • ChEMBL
  • Inhibition of Mycobacterium tuberculosis pantothenate synthetase using pantoic acid as substrate and beta-alanine as reactant assessed as NAD+ formation by spectrophotmetry in presence of NADH
  • ChEMBL
  • Inhibition of Mycobacterium tuberculosis pantothenate synthetase expressed in Escherichia coli

Reagent availability

No reagent availability information for this target.

Bibliographic References

8 literature references were collected for this gene.

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Gene identifier Rv3602c (Mycobacterium tuberculosis), Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme)
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